Ontology highlight
ABSTRACT:
SUBMITTER: Hubbard ME
PROVIDER: S-EPMC5451806 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Hubbard M E ME Jove M M Loadman P M PM Phillips R M RM Twelves C J CJ Smye S W SW
Royal Society open science 20170524 5
The tumour vasculature and microenvironment is complex and heterogeneous, contributing to reduced delivery of cancer drugs to the tumour. We have developed an <i>in silico</i> model of drug transport in a tumour cord to explore the effect of different drug regimes over a 72 h period and how changes in pharmacokinetic parameters affect tumour exposure to the cytotoxic drug doxorubicin. We used the model to describe the radial and axial distribution of drug in the tumour cord as a function of chan ...[more]