Statistical Mechanics of Allosteric Enzymes.
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ABSTRACT:
SUBMITTER: Einav T
PROVIDER: S-EPMC5452729 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Publications
Statistical Mechanics of Allosteric Enzymes.
Einav Tal T Mazutis Linas L Phillips Rob R
The journal of physical chemistry. B 20160429 26
The concept of allostery in which macromolecules switch between two different conformations is a central theme in biological processes ranging from gene regulation to cell signaling to enzymology. Allosteric enzymes pervade metabolic processes, yet a simple and unified treatment of the effects of allostery in enzymes has been lacking. In this work, we take a step toward this goal by modeling allosteric enzymes and their interaction with two key molecular players-allosteric regulators and competi ...[more]
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