Chemopreventive effects of a low-side-effect antibiotic drug, erythromycin, on mouse intestinal tumors.
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ABSTRACT:
SUBMITTER: Hamoya T
PROVIDER: S-EPMC5453017 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
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Chemopreventive effects of a low-side-effect antibiotic drug, erythromycin, on mouse intestinal tumors.
Hamoya Takahiro T Miyamoto Shingo S Tomono Susumu S Fujii Gen G Nakanishi Ruri R Komiya Masami M Tamura Shuya S Fujimoto Kyoko K Toshima Jiro J Wakabayashi Keiji K Mutoh Michihiro M
Journal of clinical biochemistry and nutrition 20170414 3
It is important to establish effective methods for preventing colorectal cancer because the number of colorectal cancer deaths is increasing. Erythromycin one of the macrolide antibiotics, has been shown to exert pleiotropic effects, such as anti-inflammatory and anti-oxidative effects, on mammalian cells. In the present study, we aimed to evaluate the preventive effects of erythromycin on intestinal carcinogenesis. We first confirmed that erythromycin suppresses the transcriptional activity of ...[more]
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