Ontology highlight
ABSTRACT:
SUBMITTER: Tasaki E
PROVIDER: S-EPMC5453025 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Tasaki Eisuke E Matsumoto Shotaro S Tada Hisashi H Kurahashi Toshihiro T Zhang Xuhong X Fujii Junichi J Utsumi Toshihiko T Iuchi Yoshihito Y
Journal of clinical biochemistry and nutrition 20170501 3
Peroxiredoxin (PRDX), a newly discovered antioxidant enzyme, has an important role in hydrogen peroxide reduction. Among six PRDX genes (PRDX1-6) in mammals, PRDX4 gene is alternatively spliced to produce the somatic cell form (PRDX4) and the testis specific form (PRDX4t). In our previous study, PRDX4 knockout mice displayed testicular atrophy with an increase in cell death due to oxidative stress. However, the antioxidant function of PRDX4t is unknown. In this study, we demonstrate that PRDX4t ...[more]