Unknown

Dataset Information

0

Epigenetic modification in chromatin machinery and its deregulation in pediatric brain tumors: Insight into epigenetic therapies.

ABSTRACT: Malignancies are characterized by the reprogramming of epigenetic patterns. This reprogramming includes gains or losses in DNA methylation and disruption of normal patterns of covalent histone modifications, which are associated with changes in chromatin remodeling processes. This review will focus on the mechanisms underlying this reprogramming and, specifically, on the role of histone modification in chromatin machinery and the modifications in epigenetic processes occurring in brain cancer, with a specific focus on epigenetic therapies for pediatric brain tumors.

SUBMITTER: Maury E 

PROVIDER: S-EPMC5453195 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Epigenetic modification in chromatin machinery and its deregulation in pediatric brain tumors: Insight into epigenetic therapies.

Maury Eleonore E   Hashizume Rintaro R  

Epigenetics 20170106 5

Malignancies are characterized by the reprogramming of epigenetic patterns. This reprogramming includes gains or losses in DNA methylation and disruption of normal patterns of covalent histone modifications, which are associated with changes in chromatin remodeling processes. This review will focus on the mechanisms underlying this reprogramming and, specifically, on the role of histone modification in chromatin machinery and the modifications in epigenetic processes occurring in brain cancer, w  ...[more]

Similar Datasets

Unknown Epigenetic deregulation in pediatric acute lymphoblastic leukemia.
| S-EPMC4053464 | biostudies-literature
Unknown Insight into the machinery that oils chromatin dynamics.
| S-EPMC5214059 | biostudies-literature
Unknown Mutations in chromatin machinery and pediatric high-grade glioma.
| S-EPMC4803494 | biostudies-literature
Unknown Use of Antiangiogenic Therapies in Pediatric Solid Tumors.
| S-EPMC7827326 | biostudies-literature
Unknown Acetylation of H2A.Z is a key epigenetic modification associated with gene deregulation and epigenetic remodeling in cancer.
| S-EPMC3266038 | biostudies-literature
Unknown Immunotherapy for Pediatric Brain Tumors.
| S-EPMC5664064 | biostudies-literature
Unknown Chromatin modification by SUMO-1 stimulates the promoters of translation machinery genes.
| S-EPMC3488252 | biostudies-literature
Unknown Molecular Imaging in Pediatric Brain Tumors.
| S-EPMC6966547 | biostudies-literature
Unknown Deregulation of ?-synuclein in Parkinson's disease: Insight from epigenetic structure and transcriptional regulation of SNCA.
| S-EPMC5557282 | biostudies-literature
Unknown Epigenetic changes in pediatric solid tumors: promising new targets.
| S-EPMC3691809 | biostudies-literature