Ontology highlight
ABSTRACT:
SUBMITTER: Juneja M
PROVIDER: S-EPMC5453412 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Juneja Manisha M Kobelt Dennis D Walther Wolfgang W Voss Cynthia C Smith Janice J Specker Edgar E Neuenschwander Martin M Gohlke Björn-Oliver BO Dahlmann Mathias M Radetzki Silke S Preissner Robert R von Kries Jens Peter JP Schlag Peter Michael PM Stein Ulrike U
PLoS biology 20170601 6
MACC1 (Metastasis Associated in Colon Cancer 1) is a key driver and prognostic biomarker for cancer progression and metastasis in a large variety of solid tumor types, particularly colorectal cancer (CRC). However, no MACC1 inhibitors have been identified yet. Therefore, we aimed to target MACC1 expression using a luciferase reporter-based high-throughput screening with the ChemBioNet library of more than 30,000 compounds. The small molecules lovastatin and rottlerin emerged as the most potent M ...[more]