A complete tool set for molecular QTL discovery and analysis.
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ABSTRACT:
SUBMITTER: Delaneau O
PROVIDER: S-EPMC5454369 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Publications
A complete tool set for molecular QTL discovery and analysis.
Delaneau Olivier O Ongen Halit H Brown Andrew A AA Fort Alexandre A Panousis Nikolaos I NI Dermitzakis Emmanouil T ET
Nature communications 20170518
Population scale studies combining genetic information with molecular phenotypes (for example, gene expression) have become a standard to dissect the effects of genetic variants onto organismal phenotypes. These kinds of data sets require powerful, fast and versatile methods able to discover molecular Quantitative Trait Loci (molQTL). Here we propose such a solution, QTLtools, a modular framework that contains multiple new and well-established methods to prepare the data, to discover proximal an ...[more]
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