Signal recognition particle prevents N-terminal processing of bacterial membrane proteins.
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ABSTRACT:
SUBMITTER: Ranjan A
PROVIDER: S-EPMC5454389 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Publications
Signal recognition particle prevents N-terminal processing of bacterial membrane proteins.
Ranjan Amitabh A Mercier Evan E Bhatt Arshiya A Wintermeyer Wolfgang W
Nature communications 20170518
Bacterial proteins are synthesized with an N-formylated amino-terminal methionine, and N-formylated peptides elicit innate-immunity responses against bacterial infections. However, the source of these formylated peptides is not clear, as most bacterial proteins are co-translationally deformylated by peptide deformylase. Here we develop a deformylation assay with translating ribosomes as substrates, to show that the binding of the signal recognition particle (SRP) to signal sequences in nascent p ...[more]
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