Ontology highlight
ABSTRACT:
SUBMITTER: Weiskopf K
PROVIDER: S-EPMC5454476 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Weiskopf Kipp K Anderson Katie L KL Ito Daisuke D Schnorr Peter J PJ Tomiyasu Hirotaka H Ring Aaron M AM Bloink Kristin K Efe Jem J Rue Sarah S Lowery David D Barkal Amira A Prohaska Susan S McKenna Kelly M KM Cornax Ingrid I O'Brien Timothy D TD O'Sullivan M Gerard MG Weissman Irving L IL Modiano Jaime F JF
Cancer immunology research 20161114 12
Cancer immunotherapies hold much promise, but their potential in veterinary settings has not yet been fully appreciated. Canine lymphomas are among the most common tumors of dogs and bear remarkable similarity to human disease. In this study, we examined the combination of CD47 blockade with anti-CD20 passive immunotherapy for canine lymphoma. The CD47/SIRPα axis is an immune checkpoint that regulates macrophage activation. In humans, CD47 is expressed on cancer cells and enables evasion from ph ...[more]