Ontology highlight
ABSTRACT:
SUBMITTER: Huang H
PROVIDER: S-EPMC545492 | biostudies-literature | 2005 Feb
REPOSITORIES: biostudies-literature
Huang Haojie H Regan Kevin M KM Wang Fang F Wang Diping D Smith David I DI van Deursen Jan M A JM Tindall Donald J DJ
Proceedings of the National Academy of Sciences of the United States of America 20050124 5
Forkhead transcription factors FOXO1 (FKHR), FOXO3a (FKHRL1), and FOXO4 (AFX) play a pivotal role in tumor suppression by inducing growth arrest and apoptosis. Loss of function of these factors due to phosphorylation and proteasomal degradation has been implicated in cell transformation and malignancy. However, the ubiquitin ligase necessary for the ubiquitination of the FOXO factors and the relevance of this regulation to tumorigenesis have not been characterized. Here we demonstrate that Skp2, ...[more]