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Exploiting Epigenetic Alterations in Prostate Cancer.

ABSTRACT: Prostate cancer affects an increasing number of men worldwide and is a leading cause of cancer-associated deaths. Beside genetic mutations, many epigenetic alterations including DNA and histone modifications have been identified in clinical prostate tumor samples. They have been linked to aberrant activity of enzymes and reader proteins involved in these epigenetic processes, leading to the search for dedicated inhibitory compounds. In the wake of encouraging anti-tumor efficacy results in preclinical models, epigenetic modulators addressing different targets are now being tested in prostate cancer patients. In addition, the assessment of microRNAs as stratification biomarkers, and early clinical trials evaluating suppressor microRNAs as potential prostate cancer treatment are being discussed.

SUBMITTER: Baumgart SJ

PROVIDER: S-EPMC5454930 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Exploiting Epigenetic Alterations in Prostate Cancer.

Baumgart Simon J SJ Haendler Bernard B

International journal of molecular sciences 20170509 5

Prostate cancer affects an increasing number of men worldwide and is a leading cause of cancer-associated deaths. Beside genetic mutations, many epigenetic alterations including DNA and histone modifications have been identified in clinical prostate tumor samples. They have been linked to aberrant activity of enzymes and reader proteins involved in these epigenetic processes, leading to the search for dedicated inhibitory compounds. In the wake of encouraging anti-tumor efficacy results in precl ...[more]

PMID: 28486411

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