Ontology highlight
ABSTRACT:
SUBMITTER: Phan AT
PROVIDER: S-EPMC545538 | biostudies-literature | 2005 Jan
REPOSITORIES: biostudies-literature
Phan Anh Tuân AT Kuryavyi Vitaly V Ma Jin-Biao JB Faure Aurélie A Andréola Marie-Line ML Patel Dinshaw J DJ
Proceedings of the National Academy of Sciences of the United States of America 20050106 3
We report on the NMR-based solution structure of the 93del d(GGGGTGGGAGGAGGGT) aptamer, a potent nanomolar inhibitor of HIV-1 integrase. This guanine-rich DNA sequence adopts an unusually stable dimeric quadruplex architecture in K+ solution. Within each 16-nt monomer subunit, which contains one A.(G.G.G.G) pentad sandwiched between two G.G.G.G tetrads, all G-stretches are parallel, and all guanines are anti with the exception of G1, which is syn. Dimer formation is achieved through mutual pairi ...[more]