Ontology highlight
ABSTRACT:
SUBMITTER: Chamian F
PROVIDER: S-EPMC545584 | biostudies-literature | 2005 Feb
REPOSITORIES: biostudies-literature
Chamian Francesca F Lowes Michelle A MA Lin Shao-Lee SL Lee Edmund E Kikuchi Toyoko T Gilleaudeau Patricia P Sullivan-Whalen Mary M Cardinale Irma I Khatcherian Artemis A Novitskaya Inna I Wittkowski Knut M KM Krueger James G JG
Proceedings of the National Academy of Sciences of the United States of America 20050125 6
Psoriasis vulgaris, a skin disease that is considered to be the result of a type 1 autoimmune response, provides an opportunity for studying the changes that occur in a target-diseased tissue during innovative immunotherapies. To gain a more comprehensive picture of the response to an approved biological therapy, we studied alfacept, which is a CD2 binding fusion protein. We examined T cells, dendritic cells (DCs), and expression of a number of inflammatory genes. In 22 patients, 55% demonstrate ...[more]