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TNF-? -308 A allele is associated with an increased risk of distant metastasis in rectal cancer patients from Southwestern China.

ABSTRACT: Tumor necrosis factor-? (TNF-?), an important factor in systematic inflammation, is reportedly involved in several cancer types. The TNF-? -308 G>A (rs1800629) polymorphism in the promoter region influences TNF-? production. The association between TNF-? -308 G>A polymorphism and colorectal cancer (CRC) is not fully understood, especially the connections between TNF-? -308 G>A polymorphism and clinical features of CRC. In this study, TNF-? -308 G>A polymorphism was genotyped in 1140 individuals with or without CRC from Southwestern China. In case-control studies, we found no association between TNF-? -308 G>A polymorphism and CRC risk. Analysis of the correlations between TNF-? -308 G>A polymorphism and clinical features of CRC revealed that TNF-? -308 A allele was associated with higher body mass index (BMI) larger tumor size, and distant tumor metastasis in all CRC patients. Notably, rectal cancer (a subtype of CRC) patients with TNF-? -308 A allele had a very high risk of distant tumor metastasis [odds ratio (OR) = 4.481; 95% confidence interval (CI): 2.072-9.693; P = 0.00025]. The association between TNF-? -308 A allele and distant tumor metastasis remained even significant after adjusting all clinical characteristics (OR = 7.099; 95% CI: 2.482-20.301; P = 0.000256) in rectal cancer patients. Our results suggested that TNF-? -308 A allele was significantly associated with distant tumor metastasis in rectal cancer patients.

SUBMITTER: Li Z

PROVIDER: S-EPMC5456043 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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TNF-α -308 A allele is associated with an increased risk of distant metastasis in rectal cancer patients from Southwestern China.

Li Zhen Z Li Shu-An SA Sun Ya Y Liu Yu Y Li Wen-Liang WL Yang Li L Duan Yong Y Li Jingyu J Guo Hao H Zou Tian-Ning TN Li Yunlong Y Wang Kun-Hua KH

PloS one 20170602 6

Tumor necrosis factor-α (TNF-α), an important factor in systematic inflammation, is reportedly involved in several cancer types. The TNF-α -308 G>A (rs1800629) polymorphism in the promoter region influences TNF-α production. The association between TNF-α -308 G>A polymorphism and colorectal cancer (CRC) is not fully understood, especially the connections between TNF-α -308 G>A polymorphism and clinical features of CRC. In this study, TNF-α -308 G>A polymorphism was genotyped in 1140 individuals ...[more]

PMID: 28575042

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Dataset Information

TNF-? -308 A allele is associated with an increased risk of distant metastasis in rectal cancer patients from Southwestern China.

Publications

TNF-α -308 A allele is associated with an increased risk of distant metastasis in rectal cancer patients from Southwestern China.

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