Ontology highlight
ABSTRACT:
SUBMITTER: Martini M
PROVIDER: S-EPMC5456633 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Martini Maike M Hegger Patricia S PS Schädel Nicole N Minsky Burcu B BB Kirchhof Manuel M Scholl Sebastian S Southan Alexander A Tovar Günter E M GEM Boehm Heike H Laschat Sabine S
Materials (Basel, Switzerland) 20160930 10
Polyelectrolyte hydrogels play an important role in tissue engineering and can be produced from natural polymers, such as the glycosaminoglycan hyaluronan. In order to control charge density and mechanical properties of hyaluronan-based hydrogels, we developed cross-linkers with a neutral or positively charged triazole core with different lengths of spacer arms and two terminal maleimide groups. These cross-linkers react with thiolated hyaluronan in a fast, stoichiometric thio-Michael addition. ...[more]