Ontology highlight
ABSTRACT:
SUBMITTER: van Lessen M
PROVIDER: S-EPMC5457137 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
van Lessen Max M Shibata-Germanos Shannon S van Impel Andreas A Hawkins Thomas A TA Rihel Jason J Schulte-Merker Stefan S
eLife 20170512
The lymphatic system controls fluid homeostasis and the clearance of macromolecules from interstitial compartments. In mammals brain lymphatics were only recently discovered, with significant implications for physiology and disease. We examined zebrafish for the presence of brain lymphatics and found loosely connected endothelial cells with lymphatic molecular signature covering parts of the brain without forming endothelial tubular structures. These brain lymphatic endothelial cells (BLECs) der ...[more]