Ontology highlight
ABSTRACT:
SUBMITTER: Xu Z
PROVIDER: S-EPMC5457157 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Xu Zhenjie Z Schaedel Laura L Portran Didier D Aguilar Andrea A Gaillard Jérémie J Marinkovich M Peter MP Théry Manuel M Nachury Maxence V MV
Science (New York, N.Y.) 20170401 6335
Eukaryotic cells rely on long-lived microtubules for intracellular transport and as compression-bearing elements. We considered that long-lived microtubules are acetylated inside their lumen and that microtubule acetylation may modify microtubule mechanics. Here, we found that tubulin acetylation is required for the mechanical stabilization of long-lived microtubules in cells. Depletion of the tubulin acetyltransferase TAT1 led to a significant increase in the frequency of microtubule breakage. ...[more]