Ontology highlight
ABSTRACT:
SUBMITTER: Fu B
PROVIDER: S-EPMC5457443 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Fu Bishi B Zhao Mengmeng M Wang Lingyan L Patil Girish G Smith Jennifer A JA Juncadella Ignacio J IJ Zuvela-Jelaska Ljiljana L Dorf Martin E ME Li Shitao S
Scientific reports 20170602 1
Interferon regulatory factor 5 (IRF5) is a key transcription factor of innate immunity, which plays an important role in host restriction to viral infection and inflammation. Genome-wide association studies have implied the association of IRF5 with several autoimmune diseases, including systemic lupus erythematosus (SLE), Sjogren's syndrome, inflammatory bowel disease and multiple sclerosis. However, the regulation of IRF5-mediated immunity is not well understood. To uncover new regulators in IR ...[more]