Ontology highlight
ABSTRACT:
SUBMITTER: Rouvinski A
PROVIDER: S-EPMC5457521 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Rouvinski Alexander A Dejnirattisai Wanwisa W Guardado-Calvo Pablo P Vaney Marie-Christine MC Sharma Arvind A Duquerroy Stéphane S Supasa Piyada P Wongwiwat Wiyada W Haouz Ahmed A Barba-Spaeth Giovanna G Mongkolsapaya Juthathip J Rey Félix A FA Screaton Gavin R GR
Nature communications 20170523
A problem in the search for an efficient vaccine against dengue virus is the immunodominance of the fusion loop epitope (FLE), a segment of the envelope protein E that is buried at the interface of the E dimers coating mature viral particles. Anti-FLE antibodies are broadly cross-reactive but poorly neutralizing, displaying a strong infection enhancing potential. FLE exposure takes place via dynamic 'breathing' of E dimers at the virion surface. In contrast, antibodies targeting the E dimer epit ...[more]