Dataset Information

Dietary micronutrient intake and its relationship with arsenic metabolism in Mexican women.

ABSTRACT: Concentrations of inorganic arsenic (iAs) metabolites in urine present intra- and interindividual variations, which are determined not only by the magnitude of exposure to iAs, but also by differences in genetic, environmental and dietary factors.To evaluate whether differences in dietary intake of selected micronutrients are associated with the metabolism of iAs.The intake of 21 micronutrients was estimated for 1027 women living in northern Mexico using a food frequency questionnaire. Concentration of urinary metabolites of iAs was determined by high performance liquid chromatography inductively coupled plasma mass spectrometry (HPLC-ICP-MS) and the proportion of iAs metabolites was calculated (%iAs, monomethylarsonic acid [%MMA] and dimethylarsinic acid [%DMA]), as well as ratios corresponding to the first (MMA/iAs), second (DMA/MMA) and total methylation (DMA/iAs).After adjustment for covariates, it was found that methionine, choline, folate, vitamin B12, Zn, Se and vitamin C favor elimination of iAs mainly by decreasing the %MMA and/or increasing %DMA in urine.Our results confirm that diet contributes to the efficiency of iAs elimination. Further studies are needed to assess the feasibility of dietary interventions that modulate the metabolism of iAs and the consequent risk of diseases related to its exposure.

SUBMITTER: Lopez-Carrillo L

PROVIDER: S-EPMC5457700 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Dietary micronutrient intake and its relationship with arsenic metabolism in Mexican women.

López-Carrillo Lizbeth L Gamboa-Loira Brenda B Becerra Wendy W Hernández-Alcaraz César C Hernández-Ramírez Raúl Ulises RU Gandolfi A Jay AJ Franco-Marina Francisco F Cebrián Mariano E ME

Environmental research 20160823

<h4>Introduction</h4>Concentrations of inorganic arsenic (iAs) metabolites in urine present intra- and interindividual variations, which are determined not only by the magnitude of exposure to iAs, but also by differences in genetic, environmental and dietary factors.<h4>Objective</h4>To evaluate whether differences in dietary intake of selected micronutrients are associated with the metabolism of iAs.<h4>Methods</h4>The intake of 21 micronutrients was estimated for 1027 women living in northern ...[more]

PMID: 27565879

Similar Datasets

Project description:ObjectivesBacterial vaginosis (BV), a clinical condition characterized by decreased vaginal Lactobacillus spp., is difficult to treat. We examined associations between micronutrient intake and a low-Lactobacillus vaginal microbiota as assessed by molecular methods (termed "molecular-BV").MethodsThis cross-sectional analysis utilized data collected at the baseline visit of the Hormonal Contraception Longitudinal Study, a cohort of reproductive-aged women followed over 2 years while initiating or ceasing hormonal contraception (HC). The Block Brief 2000 Food Frequency Questionnaire was administered and micronutrient intakes were ranked. Vaginal microbiota composition was assessed using 16S rRNA gene amplicon sequencing and clustered into community state types (CSTs) based on the types and relative abundance of bacteria detected. Associations between the lowest estimated quartile intake of nutrients and having a low-Lactobacillus CST (molecular-BV) were evaluated by logistic regression. Separate models were built for each nutrient controlling for age, body mass index, behavioral factors, HC use and total energy intake. We also conducted a literature review of existing data on associations between micronutrient intakes and BV.ResultsSamples from 104 women were included in this analysis. Their mean age was 25.8?years (SD 4.3), 29.8% were African American, 48.1% were using HC, and 25% had molecular-BV. In adjusted multivariable analyses, the lowest quartile of betaine intake was associated with an increased odds of molecular-BV (aOR 9.2, p value <?0.01, [CI 2.4-35.0]).ConclusionsThis is the first study to assess the association between estimated micronutrient intake and molecular-BV. Lower energy-adjusted intake of betaine was associated with an increased risk of molecular-BV. Betaine might have direct effects on the vaginal microenvironment or may be mediated through the gut microbiota. Additional research is needed to determine reproducibility of this finding and whether improved intake of select micronutrients such as betaine decreases the risk of BV and its sequelae.

Dataset Information

Dietary micronutrient intake and its relationship with arsenic metabolism in Mexican women.

Publications

Dietary micronutrient intake and its relationship with arsenic metabolism in Mexican women.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets