Ontology highlight
ABSTRACT:
SUBMITTER: Hanker AB
PROVIDER: S-EPMC5457707 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Hanker Ariella B AB Brewer Monica Red MR Sheehan Jonathan H JH Koch James P JP Sliwoski Gregory R GR Nagy Rebecca R Lanman Richard R Berger Michael F MF Hyman David M DM Solit David B DB He Jie J Miller Vincent V Cutler Richard E RE Lalani Alshad S AS Cross Darren D Lovly Christine M CM Meiler Jens J Arteaga Carlos L CL
Cancer discovery 20170308 6
We report a <i>HER2</i><sup>T798I</sup> gatekeeper mutation in a patient with <i>HER2</i><sup>L869R</sup>-mutant breast cancer with acquired resistance to neratinib. Laboratory studies suggested that <i>HER2</i><sup>L869R</sup> is a neratinib-sensitive, gain-of-function mutation that upon dimerization with mutant HER3<sup>E928G</sup>, also present in the breast cancer, amplifies HER2 signaling. The patient was treated with neratinib and exhibited a sustained partial response. Upon clinical progr ...[more]