Dataset Information

Accuracy, precision, and reproducibility of myocardial T1 mapping: A comparison of four T1 estimation algorithms for modified look-locker inversion recovery (MOLLI).

ABSTRACT:

Purpose

To compare the accuracy and precision of four different T1 estimation algorithms for modified Look-Locker inversion recovery (MOLLI).

Methods

Four T1 estimation algorithms, including the original fit, inversion group (IG) fit, instantaneous signal loss simulation (InSiL), and Bloch equation simulation with slice profile correction (BLESSPC) were studied. T1 estimation accuracy, precision, reproducibility, and sensitivity to heart rate (HR), flip angle (FA), and acquisition scheme (AcS) variations were compared in simulation, phantom, and volunteer studies.

Results

T1 estimation accuracy of IG (-2.4% ± 3.9%) and original fit (-3.2% ± 1.4%) were worse than BLESSPC (0.2% ± 1.5%) and InSiL (-0.7% ± 2.1%). The original fit had the best precision for T1 from 409-1884 ms for the same FA (0.67% ± 0.16% versus 0.90% ± 0.23% using IG, 0.78% ± 0.11% using InSiL, 0.77% ± 0.12% using BLESSPC). BLESSPC generated the most consistent in vivo T1 values over different FAs and AcS, and the T1 estimation reproducibility was similar (P > 0.3) among the four methods when FA = 35°. When using FA = 50°, the reproducibility was significantly improved only when using BLESSPC (1.6% ± 0.9 versus 2.6% ± 1.9%, P < 0.05).

Conclusion

BLESSPC has superior accuracy and is the least sensitive to FA, HR, and AcS variations. T1 estimation using BLESSPC and FA = 50° is superior to conventional MOLLI with FA = 35° in accuracy and precision. Further clinical studies in varying pathological conditions are warranted to confirm our findings. Magn Reson Med 78:1746-1756, 2017. © 2016 International Society for Magnetic Resonance in Medicine.

SUBMITTER: Shao J

PROVIDER: S-EPMC5457913 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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Publications

Accuracy, precision, and reproducibility of myocardial T1 mapping: A comparison of four T1 estimation algorithms for modified look-locker inversion recovery (MOLLI).

Shao Jiaxin J Liu Dapeng D Sung Kyunghyun K Nguyen Kim-Lien KL Hu Peng P

Magnetic resonance in medicine 20161204 5

<h4>Purpose</h4>To compare the accuracy and precision of four different T1 estimation algorithms for modified Look-Locker inversion recovery (MOLLI).<h4>Methods</h4>Four T1 estimation algorithms, including the original fit, inversion group (IG) fit, instantaneous signal loss simulation (InSiL), and Bloch equation simulation with slice profile correction (BLESSPC) were studied. T1 estimation accuracy, precision, reproducibility, and sensitivity to heart rate (HR), flip angle (FA), and acquisition ...[more]

PMID: 27917529

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Project description:Stress and rest T1-mapping may assess for myocardial ischemia and extracellular volume (ECV). However, the stress T1 response is method-dependent, and underestimation may lead to misdiagnosis. Further, ECV quantification may be affected by time, as well as the number and dosage of gadolinium (Gd) contrast administered. We compared two commonly available T1-mapping approaches in their stress T1 response and ECV measurement stability. Healthy subjects (n = 10, 50% female, 35 ± 8 years) underwent regadenoson stress CMR (1.5 T) on two separate days. Prototype ShMOLLI 5(1)1(1)1 sequence was used to acquire consecutive mid-ventricular T1-maps at rest, stress and post-Gd contrast to track the T1 time evolution. For comparison, standard MOLLI sequences were used: MOLLI 5(3)3 Low (256 matrix) & High (192 matrix) Heart Rate (HR) to acquire rest and stress T1-maps, and MOLLI 4(1)3(1)2 Low & High HR for post-contrast T1-maps. Stress and rest myocardial blood flow (MBF) maps were acquired after IV Gd contrast (0.05 mmol/kg each). Stress T1 reactivity (delta T1) was defined as the relative percentage increase in native T1 between rest and stress. Myocardial T1 values for delta T1 (dT1) and ECV were calculated. Residuals from the identified time dependencies were used to assess intra-method variability. ShMOLLI achieved a greater stress T1 response compared to MOLLI Low and High HR (peak dT1 = 6.4 ± 1.7% vs. 4.8 ± 1.3% vs. 3.8 ± 1.0%, respectively; both p < 0.0001). ShMOLLI dT1 correlated strongly with stress MBF (r = 0.77, p < 0.001), compared to MOLLI Low HR (r = 0.65, p < 0.01) and MOLLI High HR (r = 0.43, p = 0.07). ShMOLLI ECV was more stable to gadolinium dose with less time drift (0.006-0.04% per minute) than MOLLI variants. Overall, ShMOLLI demonstrated less intra-individual variability than MOLLI variants for stress T1 and ECV quantification. Power calculations indicate up to a fourfold (stress T1) and 7.5-fold (ECV) advantage in sample-size reduction using ShMOLLI. Our results indicate that ShMOLLI correlates strongly with increased MBF during regadenoson stress and achieves a significantly higher stress T1 response, greater effect size, and greater ECV measurement stability compared with the MOLLI variants tested.

Dataset Information

Accuracy, precision, and reproducibility of myocardial T1 mapping: A comparison of four T1 estimation algorithms for modified look-locker inversion recovery (MOLLI).

Purpose

Methods

Results

Conclusion

Publications

Accuracy, precision, and reproducibility of myocardial T1 mapping: A comparison of four T1 estimation algorithms for modified look-locker inversion recovery (MOLLI).

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