Ontology highlight
ABSTRACT:
SUBMITTER: Wang J
PROVIDER: S-EPMC545811 | biostudies-literature | 2005 Jan
REPOSITORIES: biostudies-literature
Wang Jing J Iwasaki Hiromi H Krivtsov Andrei A Febbo Phillip G PG Thorner Aaron R AR Ernst Patricia P Anastasiadou Ema E Kutok Jeffery L JL Kogan Scott C SC Zinkel Sandra S SS Fisher Jill K JK Hess Jay L JL Golub Todd R TR Armstrong Scott A SA Akashi Koichi K Korsmeyer Stanley J SJ
The EMBO journal 20050106 2
Chromosomal translocations that fuse the mixed lineage leukemia (MLL) gene with multiple partners typify acute leukemias of infancy as well as therapy-related leukemias. We utilized a conditional knockin strategy to bypass the embryonic lethality caused by MLL-CBP expression and to assess the immediate effects of induced MLL-CBP expression on hematopoiesis. Within days of activating MLL-CBP, the fusion protein selectively expanded granulocyte/macrophage progenitors (GMP) and enhanced their self- ...[more]