Ontology highlight
ABSTRACT:
SUBMITTER: Daquinag AC
PROVIDER: S-EPMC5458115 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Daquinag Alexes C AC Dadbin Ali A Snyder Brad B Wang Xiaoping X Sahin Aysegul A AA Ueno Naoto T NT Kolonin Mikhail G MG
Molecular therapy oncolytics 20170517
Adipose stromal cells (ASCs) have been identified as a mesenchymal cell population recruited from white adipose tissue (WAT) by tumors and supporting cancer progression. We have previously reported the existence of a non-glycanated decorin isoform (ngDCN) marking mouse ASCs. We identified a peptide CSWKYWFGEC that binds to ngDCN and hence can serve as a vehicle for ASC-directed therapy delivery. We used hunter-killer peptides composed of CSWKYWFGEC and a pro-apoptotic moiety to deplete ASCs and ...[more]