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MiR-135a inhibits tumor metastasis and angiogenesis by targeting FAK pathway.


ABSTRACT: Tumor metastasis has been the major cause of recurrence and death in patients with gastric cancer. Here, we find miR-135a has a decreased expression in the metastatic cell lines compared with its parental cell lines by analyzing microRNA array. Further results show that miR-135a is downregulated in the majority of human gastric cancer tissues and cell lines. Decreased expression of miR-135a is associated with TNM stage and poor survival. Besides, regaining miR-135a in gastric cancer cells obviously inhibits tumor growth, migration, invasion and angiogenesis by targeting focal adhesion kinase (FAK) pathway. Bioinformatics analysis and molecular experiments further prove that miR-135a is a novel downstream gene of tumor suppressor p53. Blocking FAK with its inhibitor can also enhance miR-135a expression through inducing p53. In summary, this study reveals the expression and function of miR-135a in gastric cancer and uncovers a novel regulatory mechanism of miR-135a.

SUBMITTER: Cheng Z 

PROVIDER: S-EPMC5458197 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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miR-135a inhibits tumor metastasis and angiogenesis by targeting FAK pathway.

Cheng Zhenguo Z   Liu Funan F   Zhang Hongyan H   Li Xiaodong X   Li Yanshu Y   Li Jiabin J   Liu Furong F   Cao Yu Y   Cao Liu L   Li Feng F  

Oncotarget 20170501 19


Tumor metastasis has been the major cause of recurrence and death in patients with gastric cancer. Here, we find miR-135a has a decreased expression in the metastatic cell lines compared with its parental cell lines by analyzing microRNA array. Further results show that miR-135a is downregulated in the majority of human gastric cancer tissues and cell lines. Decreased expression of miR-135a is associated with TNM stage and poor survival. Besides, regaining miR-135a in gastric cancer cells obviou  ...[more]

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