Ontology highlight
ABSTRACT:
SUBMITTER: Tejchman A
PROVIDER: S-EPMC5458255 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Tejchman Anna A Lamerant-Fayel Nathalie N Jacquinet Jean-Claude JC Bielawska-Pohl Aleksandra A Mleczko-Sanecka Katarzyna K Grillon Catherine C Chouaib Salem S Ugorski Maciej M Kieda Claudine C
Oncotarget 20170501 19
Podoplanin (PDPN), an O-glycosylated, transmembrane, mucin-type glycoprotein, is expressed by cancer associated fibroblasts (CAFs). In malignant transformation, PDPN is subjected to changes and its role is yet to be established. Here we show that it is involved in modulating the activity of the CCL21/CCR7 chemokine/receptor axis in a hypoxia-dependent manner. In the present model, breast cancer MDA-MB-231 cells and NKL3 cells express the surface CCR7 receptor for CCL21 chemokine which is a poten ...[more]