Synthesis and crystal structures of three new benzotriazolylpropanamides.
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ABSTRACT:
SUBMITTER: Amenta DS
PROVIDER: S-EPMC5458315 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
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Synthesis and crystal structures of three new benzotriazolylpropanamides.
Amenta Donna S DS Liebing Phil P Biero Julia E JE Sherman Robert J RJ Gilje John W JW Edelmann Frank T FT
Acta crystallographica. Section E, Crystallographic communications 20170526 Pt 6
The base-catalyzed Michael addition of 2-methyl-acryl-amide to benzotriazole afforded 3-(1<i>H</i>-benzotriazol-1-yl)-2-methyl-propanamide, C<sub>10</sub>H<sub>12</sub>N<sub>4</sub>O (<b>1</b>), in 32% yield in addition to small amounts of isomeric 3-(2<i>H</i>-benzotriazol-2-yl)-2-methyl-propanamide, C<sub>10</sub>H<sub>12</sub>N<sub>4</sub>O (<b>2</b>). In a similar manner, 3-(1<i>H</i>-benzotriazol-1-yl)-<i>N</i>,<i>N</i>-di-methyl-propanamide, C<sub>11</sub>H<sub>14</sub>N<sub>4</sub>O (<b>3 ...[more]
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