Ontology highlight
ABSTRACT:
SUBMITTER: Yan Q
PROVIDER: S-EPMC5458387 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Yan Qiaoling Q Shaw Neil N Qian Lanfang L Jiang Dunquan D
Acta crystallographica. Section F, Structural biology communications 20170511 Pt 6
Rv1220c from Mycobacterium tuberculosis is annotated as an O-methyltransferase (MtbOMT). Currently, no structural information is available for this protein. Here, the crystal structure of MtbOMT refined to 2.0 Å resolution is described. The structure reveals the presence of a methyltransferase fold and shows clear electron density for one molecule of S-adenosylmethionine (SAM), which was apparently bound by the protein during its production in Escherichia coli. Although the overall structure of ...[more]