Ontology highlight
ABSTRACT:
SUBMITTER: Murakami K
PROVIDER: S-EPMC5458392 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Murakami Karin K Nakano Kenji K Shimizu Toshiyuki T Ohto Umeharu U
Acta crystallographica. Section F, Structural biology communications 20170525 Pt 6
DEAH-box RNA helicase 15 (DHX15) plays important roles in RNA metabolism, including in splicing and in ribosome biogenesis. In addition, mammalian DHX15 also mediates the innate immune sensing of viral RNA. However, structural information on this protein is not available, although the structure of the fungal orthologue of this protein, Prp43, has been elucidated. Here, the crystal structure of the ADP-bound form of human DHX15 is reported at a resolution of 2.0 Å. This is the first structure to ...[more]