Ontology highlight
ABSTRACT:
SUBMITTER: Yu T
PROVIDER: S-EPMC5458556 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Yu Tao T Zhou Yongjin J YJ Wenning Leonie L Liu Quanli Q Krivoruchko Anastasia A Siewers Verena V Nielsen Jens J David Florian F
Nature communications 20170526
Production of chemicals and biofuels through microbial fermentation is an economical and sustainable alternative for traditional chemical synthesis. Here we present the construction of a Saccharomyces cerevisiae platform strain for high-level production of very-long-chain fatty acid (VLCFA)-derived chemicals. Through rewiring the native fatty acid elongation system and implementing a heterologous Mycobacteria FAS I system, we establish an increased biosynthesis of VLCFAs in S. cerevisiae. VLCFAs ...[more]