Ontology highlight
ABSTRACT:
SUBMITTER: Kallert SM
PROVIDER: S-EPMC5458557 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Kallert Sandra M SM Darbre Stephanie S Bonilla Weldy V WV Kreutzfeldt Mario M Page Nicolas N Müller Philipp P Kreuzaler Matthias M Lu Min M Favre Stéphanie S Kreppel Florian F Löhning Max M Luther Sanjiv A SA Zippelius Alfred A Merkler Doron D Pinschewer Daniel D DD
Nature communications 20170526
Viral infections lead to alarmin release and elicit potent cytotoxic effector T lymphocyte (CTL<sup>eff</sup>) responses. Conversely, the induction of protective tumour-specific CTL<sup>eff</sup> and their recruitment into the tumour remain challenging tasks. Here we show that lymphocytic choriomeningitis virus (LCMV) can be engineered to serve as a replication competent, stably-attenuated immunotherapy vector (artLCMV). artLCMV delivers tumour-associated antigens to dendritic cells for efficien ...[more]