Ontology highlight
ABSTRACT:
SUBMITTER: Hsieh FL
PROVIDER: S-EPMC5459573 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Hsieh Fu-Lien FL Higgins Matthew K MK
eLife 20170520
Antibodies are critical components of the human adaptive immune system, providing versatile scaffolds to display diverse antigen-binding surfaces. Nevertheless, most antibodies have similar architectures, with the variable immunoglobulin domains of the heavy and light chain each providing three hypervariable loops, which are varied to generate diversity. The recent identification of a novel class of antibody in humans from malaria endemic regions of Africa was therefore surprising as one hyperva ...[more]