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The association of six single nucleotide polymorphisms and their haplotypes in CDH13 with T2DM in a Han Chinese population.


ABSTRACT: T-cadherin (CDH13) is an adiponectin receptor. Genome-wide association studies have identified the CDH13 gene as one of the most important candidate genes in influencing plasma adiponectin levels. Several studies recently reported single-nucleotide polymorphisms (SNPs) in CDH13 gene were associated with T2DM. The purpose of this study was to investigate the association between T2DM and 6 SNPs (rs11646213, rs12596316, rs3865188, rs12444338, rs12051272, and rs7195409) in the CDH13 gene in a Han Chinese population. A total of 674 subjects with T2DM and 588 subjects without T2DM were genotyped using the TaqMan method. Our data showed that there was an association between the SNP-rs12596316 genotype and T2DM (P?

SUBMITTER: Li Y 

PROVIDER: S-EPMC5459737 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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The association of six single nucleotide polymorphisms and their haplotypes in CDH13 with T2DM in a Han Chinese population.

Li Yiping Y   Li Chuanyin C   Yang Ying Y   Shi Li L   Tao Wenyu W   Liu Shuyuan S   Yang Man M   Li Xianli X   Yao Yufeng Y   Xiao Chunjie C  

Medicine 20170601 22


T-cadherin (CDH13) is an adiponectin receptor. Genome-wide association studies have identified the CDH13 gene as one of the most important candidate genes in influencing plasma adiponectin levels. Several studies recently reported single-nucleotide polymorphisms (SNPs) in CDH13 gene were associated with T2DM. The purpose of this study was to investigate the association between T2DM and 6 SNPs (rs11646213, rs12596316, rs3865188, rs12444338, rs12051272, and rs7195409) in the CDH13 gene in a Han Ch  ...[more]

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