Ontology highlight
ABSTRACT:
SUBMITTER: Hessenberger M
PROVIDER: S-EPMC5460017 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Nature communications 20170531
The mitochondrial contact site and cristae organizing system (MICOS) is crucial for the formation of crista junctions and mitochondrial inner membrane architecture. MICOS contains two core components. Mic10 shows membrane-bending activity, whereas Mic60 (mitofilin) forms contact sites between inner and outer membranes. Here we report that Mic60 deforms liposomes into thin membrane tubules and thus displays membrane-shaping activity. We identify a membrane-binding site in the soluble intermembran ...[more]