Ontology highlight
ABSTRACT:
SUBMITTER: Sinha S
PROVIDER: S-EPMC5460027 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Sinha Subarna S Thomas Daniel D Chan Steven S Gao Yang Y Brunen Diede D Torabi Damoun D Reinisch Andreas A Hernandez David D Chan Andy A Rankin Erinn B EB Bernards Rene R Majeti Ravindra R Dill David L DL
Nature communications 20170531
Two genes are synthetically lethal (SL) when defects in both are lethal to a cell but a single defect is non-lethal. SL partners of cancer mutations are of great interest as pharmacological targets; however, identifying them by cell line-based methods is challenging. Here we develop MiSL (Mining Synthetic Lethals), an algorithm that mines pan-cancer human primary tumour data to identify mutation-specific SL partners for specific cancers. We apply MiSL to 12 different cancers and predict 145,891 ...[more]