Dataset Information

Irisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice.

ABSTRACT: We previously showed that Irisin, a myokine released from skeletal muscle after physical exercise, plays a central role in the control of bone mass. Here we report that treatment with recombinant Irisin prevented bone loss in hind-limb suspended mice when administered during suspension (preventive protocol) and induced recovery of bone mass when mice were injected after bone loss due to a suspension period of 4 weeks (curative protocol). MicroCT analysis of femurs showed that r-Irisin preserved both cortical and trabecular bone mineral density, and prevented a dramatic decrease of the trabecular bone volume fraction. Moreover, r-Irisin protected against muscle mass decline in the hind-limb suspended mice, and maintained the fiber cross-sectional area. Notably, the decrease of myosin type II expression in unloaded mice was completely prevented by r-Irisin administration. Our data reveal for the first time that Irisin retrieves disuse-induced bone loss and muscle atrophy. These findings may lead to development of an Irisin-based therapy for elderly immobile osteoporotic and physically disable patients, and might represent a countermeasure for astronauts subjected to microgravity-induced bone and muscle losses.

SUBMITTER: Colaianni G

PROVIDER: S-EPMC5460172 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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Irisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice.

Colaianni Graziana G Mongelli Teresa T Cuscito Concetta C Pignataro Paolo P Lippo Luciana L Spiro Giovanna G Notarnicola Angela A Severi Ilenia I Passeri Giovanni G Mori Giorgio G Brunetti Giacomina G Moretti Biagio B Tarantino Umberto U Colucci Silvia C SC Reseland Janne E JE Vettor Roberto R Cinti Saverio S Grano Maria M

Scientific reports 20170606 1

We previously showed that Irisin, a myokine released from skeletal muscle after physical exercise, plays a central role in the control of bone mass. Here we report that treatment with recombinant Irisin prevented bone loss in hind-limb suspended mice when administered during suspension (preventive protocol) and induced recovery of bone mass when mice were injected after bone loss due to a suspension period of 4 weeks (curative protocol). MicroCT analysis of femurs showed that r-Irisin preserved ...[more]

PMID: 28588307

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Dataset Information

Irisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice.

Publications

Irisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice.

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