Elevated 5hmC levels characterize DNA of the cerebellum in Parkinson's disease.
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ABSTRACT:
SUBMITTER: Stoger R
PROVIDER: S-EPMC5460211 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
Elevated 5hmC levels characterize DNA of the cerebellum in Parkinson's disease.
Stöger Reinhard R Scaife Paula J PJ Shephard Freya F Chakrabarti Lisa L
NPJ Parkinson's disease 20170201
5-methylcytosine and the oxidation product 5-hydroxymethylcytosine are two prominent epigenetic variants of the cytosine base in nuclear DNA of mammalian brains. We measured levels of 5-methylcytosine and 5-hydroxymethylcytosine by enzyme-linked immunosorbent assay in DNA from post-mortem cerebella of individuals with Parkinson's disease and age-matched controls. 5-methylcytosine levels showed no significant differences between Parkinson's disease and control DNA sample sets. In contrast, median ...[more]
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