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Elevated 5hmC levels characterize DNA of the cerebellum in Parkinson's disease.


ABSTRACT: 5-methylcytosine and the oxidation product 5-hydroxymethylcytosine are two prominent epigenetic variants of the cytosine base in nuclear DNA of mammalian brains. We measured levels of 5-methylcytosine and 5-hydroxymethylcytosine by enzyme-linked immunosorbent assay in DNA from post-mortem cerebella of individuals with Parkinson's disease and age-matched controls. 5-methylcytosine levels showed no significant differences between Parkinson's disease and control DNA sample sets. In contrast, median 5-hydroxymethylcytosine levels were almost twice as high (p?

SUBMITTER: Stoger R 

PROVIDER: S-EPMC5460211 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Elevated 5hmC levels characterize DNA of the cerebellum in Parkinson's disease.

Stöger Reinhard R   Scaife Paula J PJ   Shephard Freya F   Chakrabarti Lisa L  

NPJ Parkinson's disease 20170201


5-methylcytosine and the oxidation product 5-hydroxymethylcytosine are two prominent epigenetic variants of the cytosine base in nuclear DNA of mammalian brains. We measured levels of 5-methylcytosine and 5-hydroxymethylcytosine by enzyme-linked immunosorbent assay in DNA from post-mortem cerebella of individuals with Parkinson's disease and age-matched controls. 5-methylcytosine levels showed no significant differences between Parkinson's disease and control DNA sample sets. In contrast, median  ...[more]

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