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Association of three single nucleotide polymorphisms of ESR1with breast cancer susceptibility: a meta-analysis.


ABSTRACT: Expression of estrogen receptors is correlated with breast cancer risk, but inconsistent results have been reported. To clarify potential estrogen receptor (ESR)-related breast cancer risk, we analyzed genetic variants ofESR1 in association with breast cancer susceptibility. We performed a meta-analysis to investigate the association between rs2234693, rs1801132, and rs2046210 (single nucleotide polymorphisms ofESR1), and breast cancer risk. Our analysis included 44 case-control studies. For rs2234693, the CC genotype had a higher risk of breast cancer compared to the TT or CT genotype. For rs2046210, the AA, GA, or GA+ GG genotype had a much higher risk compared to the GG genotype. No significant association was found for the rs1801132 polymorphism with breast cancer risk. This meta-analysis demonstrates association between the rs2234693 and rs2046210 polymorphisms ofESR1 and breast cancer risk. The correlation strength between rs2234693 and breast cancer susceptibility differs in subgroup assessment by ethnicity.

SUBMITTER: Hu X 

PROVIDER: S-EPMC5460609 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature

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Association of three single nucleotide polymorphisms of ESR1with breast cancer susceptibility: a meta-analysis.

Hu Xu X   Jiang Linfei L   Tang Chenhui C   Ju Yuehong Y   Jiu Li L   Wei Yongyue Y   Guo Li L   Zhao Yang Y  

Journal of biomedical research 20170101 3


Expression of estrogen receptors is correlated with breast cancer risk, but inconsistent results have been reported. To clarify potential estrogen receptor (ESR)-related breast cancer risk, we analyzed genetic variants ofESR1 in association with breast cancer susceptibility. We performed a meta-analysis to investigate the association between rs2234693, rs1801132, and rs2046210 (single nucleotide polymorphisms ofESR1), and breast cancer risk. Our analysis included 44 case-control studies. For rs2  ...[more]

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