Ontology highlight
ABSTRACT:
SUBMITTER: Lee SE
PROVIDER: S-EPMC5460854 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Lee Seung-Eun SE Hyun Hyuk H Park Mi-Ryung MR Choi Youngsok Y Son Yeo-Jin YJ Park Yun-Gwi YG Jeong Sang-Gi SG Shin Min-Young MY Ha Hee-Jin HJ Hong Hyun-Sok HS Choi Min-Keyung MK Im Gi-Sun GS Park Eung-Woo EW Kim Young-Ho YH Park Chankyu C Kim Eun-Young EY Park Se-Pill SP
PloS one 20170606 6
Alzheimer's disease (AD) is a progressive neurodegenerative disease associated with memory loss and cognitive impairments. An AD transgenic (Tg) pig model would be useful for preclinical testing of therapeutic agents. We generated an AD Tg pig by somatic cell nuclear transfer (SCNT) using a multi-cistronic vector that harbored three AD-related genes with a total of six well-characterized mutations: hAPP (K670N/M671L, I716V, and V717I), hTau (P301L), and hPS1 (M146V and L286P). Four AD Tg cell li ...[more]