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In Situ Ellipsometric Monitoring of Gold Nanorod Metamaterials Growth.

ABSTRACT: An in situ transmission-based system has been designed to optically monitor the ellipsometry constants of a hyperbolic plasmonic metamaterial during electrochemical growth. The metamaterial, made from an array of vertically aligned gold nanorods, has demonstrated an unprecedented ability to manipulate the polarization of light using subwavelength thickness slabs, making in situ ellipsometric data a powerful tool in the controlled design of such components. In this work, we show practical proof-of-principle of this design method and rationalize the ellipsometric output on the basis of the modal properties of the nanorod metamaterial. The real-time optical monitoring setup provides excellent control and repeatability of nanostructure growth for the design of future ultrathin optical components. The performance of the ellipsometric method was also tested as a refractive index sensor. Monitoring refractive index changes near the metamaterial's epsilon near zero (ENZ) frequency showed a sensitivity on the order of 500°/RIU in the ellipsometric phase for a metamaterial that shows 250 nm/RIU sensitivity in its extinction.

SUBMITTER: Morgan F

PROVIDER: S-EPMC5460957 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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In Situ Ellipsometric Monitoring of Gold Nanorod Metamaterials Growth.

Morgan Frances F Murphy Antony A Hendren William W Wurtz Gregory G Pollard Robert J RJ

ACS applied materials & interfaces 20170510 20

An in situ transmission-based system has been designed to optically monitor the ellipsometry constants of a hyperbolic plasmonic metamaterial during electrochemical growth. The metamaterial, made from an array of vertically aligned gold nanorods, has demonstrated an unprecedented ability to manipulate the polarization of light using subwavelength thickness slabs, making in situ ellipsometric data a powerful tool in the controlled design of such components. In this work, we show practical proof-o ...[more]

PMID: 28475839

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Project description:In this work, multifunctional nanocarriers consisting of poly(sodium-4-styrenesulfonate) (PSS)/doxorubicin (DOXO)/poly-l-lysine hydrobromide (PLL)/hyaluronic acid (HA)-coated and (PSS/DOXO/PLL)2/HA-coated gold nanorods were assembled by the layer-by-layer technique with the aims of coupling the plasmonic photothermal properties of the metal nanoparticles for plasmonic hyperthermia and the chemoaction of drug DOXO for potential intended combinatorial cancer therapeutics in the future as well as providing different strategies for the controlled and sustained release of the cargo drug molecules. To do that, DOXO could be successfully loaded onto the hybrid nanoconstructs through electrostatic interactions with high efficiencies of up to ca. 78.3 ± 6.9% for the first formed drug layer and 56 ± 13% for the second one, with a total efficiency for the whole system [(PSS/DOXO/PLL)2/HA-coated NRs] of ca. 65.7 ± 1.4%. Nanohybrid internalization was observed to be enhanced by the outer HA layer, which is able to target the CD44 receptors widely overexpressed in some types of cancers as lung, breast, or ovarian ones. Hence, these nanohybrid systems might be versatile nanoplatforms to simultaneously deliver sufficient heat for therapeutic plasmonic hyperthermia and the anticancer drug. Two controlled mechanisms were proposed to modulate the release of the chemodrug, one by means of the enzymatic degradable character of the PLL layer and another by the modulation of the interactions between the polymeric layers through the exploitation of the optical properties of the hybrid particles under near infrared (NIR) laser irradiation. The combination of this bimodal therapeutic approach exerted a synergistic cytotoxic effect on both HeLa and MDA-MB-231 cancer cells in vitro. Cell death mechanisms were also analyzed, elucidating that plasmonic photothermal therapy induces cell necrosis, whereas DOXO activates the cell apoptotic pathway. Therefore, the present NIR laser-induced targeted cancer thermo/chemotherapy represents a novel targeted anticancer strategy with easy control on demand and suitable therapeutic efficacy.

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In Situ Ellipsometric Monitoring of Gold Nanorod Metamaterials Growth.

Publications

In Situ Ellipsometric Monitoring of Gold Nanorod Metamaterials Growth.

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