Ontology highlight
ABSTRACT:
SUBMITTER: Iovino F
PROVIDER: S-EPMC5461002 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Iovino Federico F Engelen-Lee Joo-Yeon JY Brouwer Matthijs M van de Beek Diederik D van der Ende Arie A Valls Seron Merche M Mellroth Peter P Muschiol Sandra S Bergstrand Jan J Widengren Jerker J Henriques-Normark Birgitta B
The Journal of experimental medicine 20170517 6
<i>Streptococcus pneumoniae</i> is the main cause of bacterial meningitis, a life-threating disease with a high case fatality rate despite treatment with antibiotics. Pneumococci cause meningitis by invading the blood and penetrating the blood-brain barrier (BBB). Using stimulated emission depletion (STED) super-resolution microscopy of brain biopsies from patients who died of pneumococcal meningitis, we observe that pneumococci colocalize with the two BBB endothelial receptors: polymeric immuno ...[more]