Ontology highlight
ABSTRACT:
SUBMITTER: Gorur A
PROVIDER: S-EPMC5461032 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Gorur Amita A Yuan Lin L Kenny Samuel J SJ Baba Satoshi S Xu Ke K Schekman Randy R
The Journal of cell biology 20170420 6
The coat protein complex II (COPII) is essential for the transport of large cargo, such as 300-nm procollagen I (PC1) molecules, from the endoplasmic reticulum (ER) to the Golgi. Previous work has shown that the CUL3-KLHL12 complex increases the size of COPII vesicles at ER exit sites to more than 300 nm in diameter and accelerates the secretion of PC1. However, the role of large COPII vesicles as PC1 transport carriers was not unambiguously demonstrated. In this study, using stochastic optical ...[more]