Ontology highlight
ABSTRACT:
SUBMITTER: Dave K
PROVIDER: S-EPMC5461110 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Dave Kashyap K Sur Inderpreet I Yan Jian J Zhang Jilin J Kaasinen Eevi E Zhong Fan F Blaas Leander L Li Xiaoze X Kharazi Shabnam S Gustafsson Charlotte C De Paepe Ayla A Månsson Robert R Taipale Jussi J
eLife 20170606
The gene desert upstream of the <i>MYC</i> oncogene on chromosome 8q24 contains susceptibility loci for several major forms of human cancer. The region shows high conservation between human and mouse and contains multiple <i>MYC</i> enhancers that are activated in tumor cells. However, the role of this region in normal development has not been addressed. Here we show that a 538 kb deletion of the entire <i>MYC</i> upstream super-enhancer region in mice results in 50% to 80% decrease in <i>Myc</i ...[more]