Ontology highlight
ABSTRACT:
SUBMITTER: Sakurai M
PROVIDER: S-EPMC5461201 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Sakurai Masayuki M Shiromoto Yusuke Y Ota Hiromitsu H Song Chunzi C Kossenkov Andrew V AV Wickramasinghe Jayamanna J Showe Louise C LC Skordalakes Emmanuel E Tang Hsin-Yao HY Speicher David W DW Nishikura Kazuko K
Nature structural & molecular biology 20170424 6
Both p150 and p110 isoforms of ADAR1 convert adenosine to inosine in double-stranded RNA (dsRNA). ADAR1p150 suppresses the dsRNA-sensing mechanism that activates MDA5-MAVS-IFN signaling in the cytoplasm. In contrast, the biological function of the ADAR1p110 isoform, which is usually located in the nucleus, is largely unknown. Here, we show that stress-activated phosphorylation of ADAR1p110 by MKK6-p38-MSK MAP kinases promotes its binding to Exportin-5 and its export from the nucleus. After trans ...[more]