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Graft-versus-Leukemia Effect Following Hematopoietic Stem Cell Transplantation for Leukemia.


ABSTRACT: The success of hematopoietic stem cell transplantation (HSCT) lies with the ability of the engrafting immune system to remove residual leukemia cells via a graft-versus-leukemia effect (GvL), caused either spontaneously post-HSCT or via donor lymphocyte infusion. GvL effects can also be initiated by allogenic mismatched natural killer cells, antigen-specific T cells, and activated dendritic cells of leukemic origin. The history and further application of this GvL effect and the main mechanisms will be discussed and reviewed in this chapter.

SUBMITTER: Dickinson AM 

PROVIDER: S-EPMC5461268 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Graft-versus-Leukemia Effect Following Hematopoietic Stem Cell Transplantation for Leukemia.

Dickinson Anne M AM   Norden Jean J   Li Shuang S   Hromadnikova Ilona I   Schmid Christoph C   Schmetzer Helga H   Jochem-Kolb Hans H  

Frontiers in immunology 20170607


The success of hematopoietic stem cell transplantation (HSCT) lies with the ability of the engrafting immune system to remove residual leukemia cells <i>via</i> a graft-versus-leukemia effect (GvL), caused either spontaneously post-HSCT or <i>via</i> donor lymphocyte infusion. GvL effects can also be initiated by allogenic mismatched natural killer cells, antigen-specific T cells, and activated dendritic cells of leukemic origin. The history and further application of this GvL effect and the mai  ...[more]

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