Ontology highlight
ABSTRACT:
SUBMITTER: Liu M
PROVIDER: S-EPMC546140 | biostudies-literature | 2005
REPOSITORIES: biostudies-literature
Liu Mingyi M Walch Heiko H Wu Shaoping S Grigoriev Andrei A
Nucleic acids research 20050107 1
We present evidence of remarkable genome-wide mobility and evolutionary expansion for a class of protein domains whose borders locate close to the borders of their encoding exons. These exon-bordering domains are more numerous and widely distributed in the human genome than other domains. They also co-occur with more diverse domains to form a larger variety of domain architectures in human proteins. A systematic comparison of nine animal genomes from nematodes to mammals revealed that exon-borde ...[more]