Prognostic value of plasma DPP4 activity in ST-elevation myocardial infarction.

ABSTRACT:

Background

Dipeptidyl peptidase-4 (DPP4) regulates blood glucose levels and inflammation, and it is also implicated in the pathophysiological process of myocardial infarction (MI). Plasma DPP4 activity (DPP4a) may provide prognostic information regarding outcomes for ST-segment elevation MI (STEMI) patients.

Methods

Blood samples were obtained from 625 consecutively admitted, percutaneous coronary intervention-treated STEMI patients with a mean age of 57 years old. DPP4a was quantified using enzymatic assays.

Results

The median follow-up period was 30 months. Multivariate Cox-regression analyses (adjusted for confounding variables) showed that a 1 U/L increase of DPP4a did not associate with risks of major adverse cardiac or cerebrovascular events (MACCE), cardiovascu

SUBMITTER: Li JW 

PROVIDER: S-EPMC5461628 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature