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Harnessing the immune response to target tumors.


ABSTRACT: Development of "immune-based targeted therapy" in oncology has limited experience with signal pathway modulation. However, as we have become better versed in understanding immune function related to anticancer response, "hints" of specific targets associated with sensitivity and resistance have been identified with targeted immune therapy. This brief review summarizes the relationship of several targeted immune therapeutics and activity associated clinical responsiveness.

SUBMITTER: Manning L 

PROVIDER: S-EPMC5461900 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Harnessing the immune response to target tumors.

Manning Luisa L   Nemunaitis John J  

F1000Research 20170518


Development of "immune-based targeted therapy" in oncology has limited experience with signal pathway modulation. However, as we have become better versed in understanding immune function related to anticancer response, "hints" of specific targets associated with sensitivity and resistance have been identified with targeted immune therapy. This brief review summarizes the relationship of several targeted immune therapeutics and activity associated clinical responsiveness. ...[more]

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