Susceptibility of ATM-deficient pancreatic cancer cells to radiation.
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ABSTRACT:
SUBMITTER: Ayars M
PROVIDER: S-EPMC5462076 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Publications
Susceptibility of ATM-deficient pancreatic cancer cells to radiation.
Ayars Michael M Eshleman James J Goggins Michael M
Cell cycle (Georgetown, Tex.) 20170428 10
Ataxia telangiectasia mutated (ATM) is inactivated in a significant minority of pancreatic ductal adenocarcinomas and may be predictor of treatment response. We determined if ATM deficiency renders pancreatic cancer cells more sensitive to fractionated radiation or commonly used chemotherapeutics. ATM expression was knocked down in three pancreatic cancer cell lines using ATM-targeting shRNA. Isogenic cell lines were tested for sensitivity to several chemotherapeutic agents and radiation. DNA re ...[more]
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