Ontology highlight
ABSTRACT:
SUBMITTER: Tezze C
PROVIDER: S-EPMC5462533 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Cell metabolism 20170525 6
Mitochondrial dysfunction occurs during aging, but its impact on tissue senescence is unknown. Here, we find that sedentary but not active humans display an age-related decline in the mitochondrial protein, optic atrophy 1 (OPA1), that is associated with muscle loss. In adult mice, acute, muscle-specific deletion of Opa1 induces a precocious senescence phenotype and premature death. Conditional and inducible Opa1 deletion alters mitochondrial morphology and function but not DNA content. Mechanis ...[more]